Dosing & Uses
Dosage Forms & Strengths
injectable solution
- 50mg/mL
injection, lyophilized powder for reconstitution
- 500mg/vial
- 1000mg/vial
oral suspension
- 200mg/5mL
tablet
- 400mg
- 800mg
capsule
- 200mg
Genital Herpes
Initial treatment: 200 mg PO q4hr while awake (5 times daily) for 10 days or 400 mg PO q8hr for 7-10 days
Intermittent treatment for recurrence: 200 mg PO q4hr while awake (5 times daily) for 5 days; initiate at earliest sign or symptom of recurrence
Chronic suppression for recurrence: 400 mg PO q12hr for up to 12 months; alternatively, 200 mg 3-5 times daily
Herpes Simplex Virus Encephalitis
10-15 mg/kg IV q8hr for 10 days; up to 14-21 days reported
Mucocutaneous Herpes Simplex Virus Infection
Treatment in immunocompromised patients
IV: 5 mg/kg q8hr for 7 days; dosing up to 14 days reported
PO (off-label): 400 mg q4hr while awake (5 times daily) for 7 days
Herpes Zoster (Shingles)
Acute treatment: 800 mg PO q4hr while awake (5 times daily) for 7-10 days
Immunocompromised patients
- 10 mg/kg IV q8hr for 7 days
- CrCl 25-50 mL/min: Full recommended IV dose q12hr
- CrCl 10-25 mL/min: Full recommended IV dose once daily
- CrCl 0-10 mL/min: 50% of recommended IV dose once daily
Varicella Zoster (Chickenpox)
>40 kg (immunocompetent): 800 mg PO q6hr for 5 days
Immunocompromised patients: 10-15 mg/kg IV q8hr for 7-10 days
Dosage Modifications
Dose adjustment based on renal clearance and normal dosage regimen
200 mg every 4 hr
- <10 mL/min/1.73 m²: 200 mg q12hr
- ≥10 mL/min/1.73 m²: 200 mg q4hr (five times daily)
400 mg every 12 hr
- <10 mL/min/1.73 m²: 200 mg q12hr
- ≥10 mL/min/1.73 m²: 400 mg q12hr
800 mg every 4 hr
- <10 mL/min/1.73 m²: 800 mg q12hr
- 10-25 mL/min/1.73 m²: 800 mg q8hr
- >25 mL/min/1.73 m²: 800 mg q4hr (five times daily)
Dose adjustment based on dosage form
Renal impairment (IV)
- CrCl 25-50 mL/min/1.73 m²: Give recommended dose q12hr
- CrCl 10-25 mL/min/1.73 m²: Give recommended dose q24hr
- CrCl <10 mL/min/1.73 m²: Give 50% of recommended dose q24hr
Renal impairment (PO)
- Normal dosage 200 mg q4hr or 400 mg q12hr and CrCl <10 mL/min/1.73 m²: Decrease to 200 mg q12hr
- Normal dosage 800 mg q4hr and CrCl 10-25 mL/min/1.73 m²: Decrease to 800 mg q8hr
- Normal dosage 800 mg q4hr and CrCl <10 mL/min/1.73 m²: Decrease to 800 mg q12hr
Herpetic Keratitis (Orphan)
Orphan designation for treatment of herpetic keratitis
Sponsor
- Cumulus Pharmaceuticals LLC; 1712 Pioneer Avenue, Suite 1377; Cheyenne, Wyoming 82001
Dosage Forms & Strengths
injectable solution
- 50mg/mL
injection, lyophilized powder for reconstitution
- 500mg/vial
- 1000mg/vial
oral suspension
- 200mg/5mL
powder for injection
- 500mg/vial
- 1g/vial
tablet
- 400mg
- 800mg
capsule
- 200mg
Neonatal Herpes Simplex Virus Infection
Following doses based on research of the NIH National Institute of Child Health and Human Development (NICHD) that updated prescribing information was based on
Infuse IV over 1 hr
PMA ≥34 weeks: 20 mg/kg IV q8hr for 21 days
PMA <34 weeks: 20 mg/kg IV q12hr for 21 days
Caution if renal function beyond the effect of prematurity occurs
Herpes Simplex Virus Encephalitis
3 months-12 years: 20 mg/kg IV q8hr for 10 days; up to 14-21 days reported
≥12 years: 10-15 mg/kg IV q8hr for 14-21 days
Mucocutaneous Herpes Simplex Virus Infection
Treatment in immunocompromised patients
<12 years: 10 mg/kg IV q8hr for 7 days
≥12 years: 5-10 mg/kg/day IV divided q8hr for 5-7 days; up to 14 days reported
Herpes Zoster (Shingles)
<12 years (immunocompromised): 20 mg/kg IV q8hr for 7 days
≥12 years (immunocompetent): 800 mg PO q4hr while awake (5 times daily) for 7-10 days
≥12 years (immunocompromised): 30 mg/kg/day IV divided q8hr for 7-10 days
Varicella Zoster (Chickenpox)
≥2 years and <40 kg: 20 mg/kg/dose PO q6hr for 5 days; not to exceed 800 mg/dose
≥40 kg: 800 mg PO q6hr for 5 days
Immunocompromised patients
- <12 years: 20 mg/kg/dose IV q8hr for 7 days
- ≥12 years: 10 mg/kg/dose IV q8hr for 7 days
Dosing Considerations
Use ideal body weight (IBW) for obese patients
Interactions
Interaction Checker
No Results

Contraindicated
Serious - Use Alternative
Significant - Monitor Closely
Minor

Contraindicated (0)
Serious - Use Alternative (5)
- amphotericin B deoxycholate
acyclovir and amphotericin B deoxycholate both increase nephrotoxicity and/or ototoxicity. Avoid or Use Alternate Drug.
- bacitracin
acyclovir and bacitracin both increase nephrotoxicity and/or ototoxicity. Avoid or Use Alternate Drug. Avoid concurrent use of bacitracin with other nephrotoxic drugs
- cidofovir
acyclovir and cidofovir both increase nephrotoxicity and/or ototoxicity. Avoid or Use Alternate Drug.
- neomycin PO
acyclovir and neomycin PO both increase nephrotoxicity and/or ototoxicity. Avoid or Use Alternate Drug.
- talimogene laherparepvec
acyclovir decreases effects of talimogene laherparepvec by pharmacodynamic antagonism. Avoid or Use Alternate Drug. Although no drug interactions studies have been performed, antiherpetic viral agents may interfere with the effectiveness of talimogene laherparepvec.
Monitor Closely (27)
- amikacin
acyclovir and amikacin both increase nephrotoxicity and/or ototoxicity. Modify Therapy/Monitor Closely.
- amoxicillin
amoxicillin, acyclovir. Either increases levels of the other by decreasing renal clearance. Use Caution/Monitor.
- capreomycin
acyclovir and capreomycin both increase nephrotoxicity and/or ototoxicity. Use Caution/Monitor.
- carboplatin
acyclovir and carboplatin both increase nephrotoxicity and/or ototoxicity. Use Caution/Monitor.
- cephaloridine
acyclovir and cephaloridine both increase nephrotoxicity and/or ototoxicity. Use Caution/Monitor.
- cisplatin
acyclovir and cisplatin both increase nephrotoxicity and/or ototoxicity. Use Caution/Monitor.
- colistin
acyclovir and colistin both increase nephrotoxicity and/or ototoxicity. Use Caution/Monitor.
- contrast media (iodinated)
acyclovir and contrast media (iodinated) both increase nephrotoxicity and/or ototoxicity. Modify Therapy/Monitor Closely.
- cyclosporine
acyclovir and cyclosporine both increase nephrotoxicity and/or ototoxicity. Modify Therapy/Monitor Closely.
- elvitegravir/cobicistat/emtricitabine/tenofovir DF
acyclovir, elvitegravir/cobicistat/emtricitabine/tenofovir DF. Either increases toxicity of the other by decreasing renal clearance. Use Caution/Monitor. Toxicity may result from coadministration of emtricitabine and tenofovir with other drugs that are also primarily excreted by glomerular filtration and/or active tubular secretion .
acyclovir and elvitegravir/cobicistat/emtricitabine/tenofovir DF both increase nephrotoxicity and/or ototoxicity. Use Caution/Monitor. - emtricitabine
acyclovir increases levels of emtricitabine by Other (see comment). Use Caution/Monitor. Comment: Coadministration of emtricitabine with drugs that reduce renal function or compete for active tubular secretion may increase serum concentrations of emtricitabine.
- gentamicin
acyclovir and gentamicin both increase nephrotoxicity and/or ototoxicity. Use Caution/Monitor.
- ioversol
acyclovir and ioversol both increase nephrotoxicity and/or ototoxicity. Modify Therapy/Monitor Closely.
- mycophenolate
acyclovir will increase the level or effect of mycophenolate by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor.
- oxaliplatin
acyclovir and oxaliplatin both increase nephrotoxicity and/or ototoxicity. Use Caution/Monitor.
- peramivir
acyclovir increases levels of peramivir by decreasing renal clearance. Use Caution/Monitor. Caution when peramivir coadministered with nephrotoxic drugs.
- pivmecillinam
pivmecillinam, acyclovir. Either increases levels of the other by decreasing renal clearance. Use Caution/Monitor.
- polymyxin B
acyclovir and polymyxin B both increase nephrotoxicity and/or ototoxicity. Use Caution/Monitor.
- probenecid
acyclovir will increase the level or effect of probenecid by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor.
- streptozocin
acyclovir and streptozocin both increase nephrotoxicity and/or ototoxicity. Use Caution/Monitor.
- tacrolimus
acyclovir and tacrolimus both increase nephrotoxicity and/or ototoxicity. Modify Therapy/Monitor Closely.
- teicoplanin
acyclovir and teicoplanin both increase nephrotoxicity and/or ototoxicity. Modify Therapy/Monitor Closely.
- temocillin
temocillin, acyclovir. Either increases levels of the other by decreasing renal clearance. Use Caution/Monitor.
- tenofovir DF
acyclovir and tenofovir DF both increase nephrotoxicity and/or ototoxicity. Use Caution/Monitor.
acyclovir increases levels of tenofovir DF by Other (see comment). Use Caution/Monitor. Comment: Coadministration of tenofovir with drugs that reduce renal function or compete for active tubular secretion may increase serum concentrations of tenofovir. - ticarcillin
ticarcillin, acyclovir. Either increases levels of the other by decreasing renal clearance. Use Caution/Monitor.
- tobramycin
acyclovir and tobramycin both increase nephrotoxicity and/or ototoxicity. Use Caution/Monitor.
- ublituximab
ublituximab decreases effects of acyclovir by immunosuppressive effects; risk of infection. Use Caution/Monitor.
Minor (62)
- aceclofenac
aceclofenac will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- acemetacin
acemetacin will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- adefovir
acyclovir and adefovir both increase nephrotoxicity and/or ototoxicity. Minor/Significance Unknown.
- aminohippurate sodium
acyclovir will increase the level or effect of aminohippurate sodium by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- aspirin
aspirin will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- aspirin rectal
aspirin rectal will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- aspirin/citric acid/sodium bicarbonate
aspirin/citric acid/sodium bicarbonate will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- astragalus
astragalus increases effects of acyclovir by pharmacodynamic synergism. Minor/Significance Unknown.
- balsalazide
balsalazide will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- bendroflumethiazide
bendroflumethiazide will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- cefadroxil
cefadroxil will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- cefamandole
cefamandole will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- cefpirome
cefpirome will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- ceftazidime
ceftazidime will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- celecoxib
celecoxib will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- cephalexin
cephalexin will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- chlorothiazide
chlorothiazide will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- chlorpropamide
acyclovir will increase the level or effect of chlorpropamide by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- chlorthalidone
chlorthalidone will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- choline magnesium trisalicylate
choline magnesium trisalicylate will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- cyclopenthiazide
cyclopenthiazide will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- diclofenac
diclofenac will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- diflunisal
diflunisal will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- etodolac
etodolac will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- fenoprofen
fenoprofen will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- flurbiprofen
flurbiprofen will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- foscarnet
acyclovir and foscarnet both increase nephrotoxicity and/or ototoxicity. Minor/Significance Unknown.
- ganciclovir
acyclovir will increase the level or effect of ganciclovir by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- hydrochlorothiazide
hydrochlorothiazide will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- ibuprofen
ibuprofen will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- ibuprofen IV
ibuprofen IV will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- indapamide
indapamide will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- indomethacin
indomethacin will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- ketoprofen
ketoprofen will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- ketorolac
ketorolac will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- ketorolac intranasal
ketorolac intranasal will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- lornoxicam
lornoxicam will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- meclofenamate
meclofenamate will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- mefenamic acid
mefenamic acid will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- meloxicam
meloxicam will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- mesalamine
mesalamine will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- methoxyflurane
acyclovir and methoxyflurane both increase nephrotoxicity and/or ototoxicity. Minor/Significance Unknown.
- methyclothiazide
methyclothiazide will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- metolazone
metolazone will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- nabumetone
nabumetone will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- naproxen
naproxen will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- oxaprozin
oxaprozin will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- parecoxib
parecoxib will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- paromomycin
acyclovir and paromomycin both increase nephrotoxicity and/or ototoxicity. Minor/Significance Unknown.
- pentamidine
acyclovir and pentamidine both increase nephrotoxicity and/or ototoxicity. Minor/Significance Unknown.
- piroxicam
piroxicam will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- rose hips
rose hips will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- salicylates (non-asa)
salicylates (non-asa) will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- salsalate
salsalate will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- streptomycin
acyclovir and streptomycin both increase nephrotoxicity and/or ototoxicity. Minor/Significance Unknown.
- sulfasalazine
sulfasalazine will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- sulindac
sulindac will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- tolfenamic acid
tolfenamic acid will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- tolmetin
tolmetin will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- valganciclovir
acyclovir will increase the level or effect of valganciclovir by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- vancomycin
acyclovir and vancomycin both increase nephrotoxicity and/or ototoxicity. Minor/Significance Unknown.
- willow bark
willow bark will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
Adverse Effects
>10%
Oral
- Malaise (≤12%)
1-10%
Parenteral
- Inflammation or phlebitis at injection site (9%)
- Nausea (7%)
- Vomiting (7%)
- Rash or hives (2%)
- Elevated transaminase levels (1-2%)
Oral
- Nausea (2-5%)
- Vomiting (≤3%)
- Diarrhea (2-3%)
- Headache (2%)
<1%
Abdominal pain
Aggression/confusion
Agitation
Alopecia
Anaphylaxis
Anemia
Angioedema
Anorexia
Ataxia
Coma
Disseminated intravascular coagulation (DIC)
Dizziness
Fatigue
Warnings
Contraindications
Hypersensitivity
Cautions
Avoid rapid infusion because of risk of renal damage
Renal failure, resulting in death, has occurred
Use with caution in immunocompromised patients (potential risk of thrombotic thrombocytopenic purpura [TTP]/hemolytic uremic syndrome [HUS])
Use with caution in patients with renal impairment
Treatment should begin within 24 hours of appearance of rash
Use with caution in patients receiving nephrotoxic drugs
Maintain adequate hydration during PO or IV therapy
Thrombocytopenic purpura/hemolytic uremic syndrome reported
Pregnancy & Lactation
Pregnancy
Drug is minimally absorbed systemically following topical route of administration, and maternal use is not expected to result in fetal exposure to drug; experience with topical acyclovir use in pregnant women over several decades, based on published literature including observational studies, has not identified a drug-associated risk of major birth defects, miscarriage or adverse maternal or fetal outcomes
Animal data
- Animal reproduction studies with systemic exposure of acyclovir have been conducted; refer to acyclovir prescribing information for additional details
Lactation
Drug is minimally absorbed systemically following topical route of administration, and breastfeeding is not expected to result in exposure of child to drug; there are no data on effects of drug on breastfed infant or on milk production; Developmental and health benefits of breastfeeding should be considered along with mother’s clinical need for therapy and any potential adverse effects on breastfed child from drug or from underlying maternal condition
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Mechanism of Action
Interferes with DNA polymerase to inhibit DNA replication via chain termination
Absorption
Absorption: PO, 15-30%
Peak serum time: 1.5-2 hr (PO); 1 hr (IV)
Distribution
Distributed widely (brain, kidney, lungs, liver, spleen, muscle, uterus, vagina, cerebrospinal fluid [CSF])
Protein bound: 9-33%
Vd: 0.8 L/kg (63.6 L)
Metabolism
Metabolized by liver (in small amounts)
Elimination
Half-life: 4 hr (Neonates); 2-3 hr (children 1-12 years); 3 hr (adults)
Excretion: Urine (62-90% as unchanged drug)
Administration
IV Incompatibilities
Blood products and protein-containing solutions
Additive: Dobutamine, dopamine, meropenem (?)
Syringe: Caffeine
Y-site: Amifostine, amsacrine, aztreonam, cefepime, dobutamine, dopamine, fludarabine, foscarnet, gemcitabine, idarubicin, levofloxacin, morphine sulfate (?), ondansetron, piperacillin-tazobactam, sargramostim, vinorelbine
IV Compatibilities
Additive: Fluconazole
Y-site (partial list): Allopurinol, ampicillin, cefazolin, cimetidine, diphenhydramine, fluconazole, heparin, linezolid, lorazepam, magnesium sulfate, potassium chloride, propofol, trimethoprim-sulfamethoxazole, vancomycin
IV Preparation
Lyophilized powder
- Reconstitute with 10 mL (500-mg vial) or 20 mL (1000-mg vial) with Sterile Water
- Do not bacteriostatic water containing benzyl alcohol
- Concentrations >10 mg/mL increase risk of phlebitis; usually recommended not to exceed 7 mg/mL in D5W
Injection
- For IV infusion, dilute solution in D5W or 0.9% NaCl to a final concentration ≤7 mg/mL. Concentrations >10 mg/mL increase the risk of phlebitis
IV Administration
For IV infusion only
Avoid rapid infusion; infuse over 1 hr at constant rate to prevent renal damage
Maintain adequate hydration
Check for phlebitis, and rotate infusion sites
Storage
Capsule, oral suspension, tablet: Store at room temperature of 15-25°C (59-77°F); protect from moisture
Powder for injection: Store undiluted vials at 15-25°C (59-77°F); following reconstitution (final concentration 50 mg/mL), solution is stable for 12 hr at room temperature
Solution for injection: Store solution at 20-25°C (68-77°F)
Reconstituted solutions: Do not refrigerate; once diluted with 0.9% NaCl or D5W, use within 24 hr
Images
BRAND | FORM. | UNIT PRICE | PILL IMAGE |
---|---|---|---|
acyclovir oral - | 200 mg capsule | ![]() | |
acyclovir oral - | 200 mg capsule | ![]() | |
acyclovir oral - | 800 mg tablet | ![]() | |
acyclovir oral - | 200 mg capsule | ![]() | |
acyclovir oral - | 400 mg tablet | ![]() | |
acyclovir oral - | 400 mg tablet | ![]() | |
acyclovir oral - | 400 mg tablet | ![]() | |
acyclovir oral - | 800 mg tablet | ![]() | |
acyclovir oral - | 400 mg tablet | ![]() | |
acyclovir oral - | 200 mg capsule | ![]() | |
acyclovir oral - | 800 mg tablet | ![]() | |
acyclovir oral - | 400 mg tablet | ![]() | |
acyclovir oral - | 200 mg capsule | ![]() | |
acyclovir oral - | 800 mg tablet | ![]() | |
acyclovir oral - | 200 mg capsule | ![]() | |
acyclovir oral - | 800 mg tablet | ![]() | |
acyclovir oral - | 400 mg tablet | ![]() | |
acyclovir oral - | 800 mg tablet | ![]() | |
acyclovir oral - | 400 mg tablet | ![]() | |
acyclovir oral - | 400 mg tablet | ![]() | |
acyclovir oral - | 200 mg capsule | ![]() | |
acyclovir oral - | 200 mg capsule | ![]() | |
acyclovir oral - | 200 mg/5 mL suspension | ![]() | |
acyclovir oral - | 200 mg/5 mL suspension | ![]() | |
acyclovir oral - | 800 mg tablet | ![]() | |
acyclovir oral - | 200 mg/5 mL suspension | ![]() | |
acyclovir oral - | 800 mg tablet | ![]() | |
acyclovir oral - | 800 mg tablet | ![]() | |
acyclovir oral - | 200 mg/5 mL suspension | ![]() | |
acyclovir topical - | 5 % ointment | ![]() | |
acyclovir topical - | 5 % ointment | ![]() | |
acyclovir topical - | 5 % ointment | ![]() | |
acyclovir topical - | 5 % ointment | ![]() | |
acyclovir topical - | 5 % ointment | ![]() | |
acyclovir topical - | 5 % cream | ![]() | |
acyclovir topical - | 5 % ointment | ![]() | |
acyclovir topical - | 5 % ointment | ![]() | |
acyclovir topical - | 5 % ointment | ![]() | |
acyclovir topical - | 5 % ointment | ![]() | |
acyclovir topical - | 5 % ointment | ![]() | |
acyclovir topical - | 5 % ointment | ![]() | |
acyclovir topical - | 5 % cream | ![]() | |
acyclovir topical - | 5 % ointment | ![]() | |
acyclovir topical - | 5 % ointment | ![]() | |
acyclovir topical - | 5 % ointment | ![]() | |
acyclovir topical - | 5 % ointment | ![]() | |
acyclovir topical - | 5 % ointment | ![]() | |
acyclovir topical - | 5 % ointment | ![]() | |
acyclovir topical - | 5 % ointment | ![]() | |
acyclovir topical - | 5 % cream | ![]() | |
acyclovir topical - | 5 % ointment | ![]() | |
acyclovir topical - | 5 % ointment | ![]() | |
acyclovir topical - | 5 % ointment | ![]() | |
Zovirax topical - | 5 % ointment | ![]() | |
Zovirax topical - | 5 % cream | ![]() |
Copyright © 2010 First DataBank, Inc.
Patient Handout
acyclovir buccal
ACYCLOVIR TABLET - BUCCAL
(ay-SYE-kloe-vir)
COMMON BRAND NAME(S): Sitavig
USES: This medication is used to treat cold sores around the mouth (caused by herpes virus) that keep coming back.Acyclovir is an antiviral drug. However, it is not a cure for the infection. The virus that causes infection continues to live in the body between outbreaks. Acyclovir makes outbreaks shorter and less severe. It helps the sores heal faster, keeps new sores from forming, and decreases pain/itching. This medication may also help reduce how long pain lasts after the sores heal.
HOW TO USE: Read the Patient Information Leaflet and Instructions for Use provided by your pharmacist before you start using acyclovir buccal tablets and each time you get a refill. If you have any questions, ask your doctor or pharmacist.Apply one tablet within one hour after you have the first symptom of a cold sore, and before a cold sore appears. Symptoms may include itching, redness, burning, or tingling. Apply the tablet on the same side of your mouth as the cold sore symptoms.Before applying the tablet, find the area in your mouth in which to place the tablet. It should be placed on the upper gum, just above the left or right incisor tooth. The incisors are the teeth just to the left and right of your two front teeth. With dry hands, remove one tablet from the blister pack and place it in your mouth with the round side facing against your gum and gently push it into place. Remove your hand from inside your mouth and gently press your finger on the outside of your upper lip for 30 seconds. This will make the tablet stick to your gum. The tablet will slowly dissolve over time and should be left in place. You may eat and drink while using this medication. Do not crush, chew, suck, or swallow the tablet.If the tablet does not stick to your upper gum or falls off within the first 6 hours after you apply it, the same tablet should be placed back onto your upper gum right away. If it still does not stay in place, apply another acyclovir tablet to your upper gum.If you accidentally swallow the tablet within the first 6 hours after placement, drink a glass of water and apply a new dose to your gum. However, if the tablet has been in place 6 hours or longer and it falls out or you swallow it, do not re-apply the tablet.Avoid doing things that may keep the buccal tablet from sticking to your gum, including touching or pressing the tablet after placement, wearing an upper denture that interferes with tablet placement, chewing gum, and brushing your teeth while the tablet is in place. You may gently rinse your mouth with water to clean your teeth while the tablet is in place. Drink plenty of liquids if you have dry mouth.This medication works best when started at the first sign of a cold sore, as directed by your doctor. It may not work as well if you delay treatment.Tell your doctor if your condition does not improve or if it worsens.
SIDE EFFECTS: Headache or pain at the application site may occur. If either of these effects lasts or gets worse, tell your doctor or pharmacist promptly.Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
PRECAUTIONS: Before using acyclovir, tell your doctor or pharmacist if you are allergic to it; or to valacyclovir; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history.Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).Do not have certain immunizations/vaccinations (such as vaccines against the varicella virus) without the consent of your doctor.During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.It is unknown if this form of acyclovir passes into breast milk. However, this medication is unlikely to harm a nursing infant. Consult your doctor before breast-feeding.
DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Acyclovir is very similar to valacyclovir. Do not use medications containing valacyclovir while using acyclovir.
OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.
NOTES: Do not share this medication with others.This medication has been prescribed for your current condition only. Do not use it later for another infection unless your doctor tells you to.
MISSED DOSE: Not applicable.
STORAGE: Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.
Information last revised March 2022. Copyright(c) 2023 First Databank, Inc.
IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.
Formulary
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