tobramycin/loteprednol ophthalmic (Rx)

Brand and Other Names:Zylet
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

tobramycin/loteprednol

ophthalmic suspension

  • 0.3/0.5%

Ocular Inflammation

Indicated for steroid-responsive ocular inflammations with risk of superficial bacterial infections

Shake vigorously before use

Instill 1-2 gtts in affected eye(s) q4-6hr; may use as frequently as q1-2hr during first 24-48 hr

Decrease frequency of administration as signs and symptoms improve; if use exceeds >20 mL evaluate therapy further

Dosage Forms & Strengths

tobramycin/loteprednol

ophthalmic suspension

  • 0.3/0.5%

Ocular Inflammation

Indicated for steroid-responsive ocular inflammations with risk of superficial bacterial infections

Shake vigorously before use

Instill 1-2 gtts in affected eye(s) q4-6hr; may use as frequently as q1-2hr during first 24-48 hr

Decrease frequency of administration as signs and symptoms improve; if use exceeds >20 mL evaluate therapy further

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Interactions

Interaction Checker

and tobramycin/loteprednol ophthalmic

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Warnings

            Contraindications

            Hypersensitivity to any component of the formulation or to other corticosteroids

            Viral, mycobacterial & fungal eye infections

            Cautions

            History of herpes simplex infections

            May exacerbate infections by nonsusceptible organisms

            Monitor IOP if used >10 d

            Bacterial keratitis reported from inadvertent contamination of multiple dose ophthalmic solution

            Immunosuppression resulting from prolonged use of steroid use may result in secondary bacterial and fungal infections; steroids may also mask symptoms of infections and enhance existing ocular infections

            Ocular hypertension and/or glaucoma reported with prolonged corticosteroid use

            Discontinue use if sensitivity reaction to tobramycin develops

            Corticosteroid use following cataract surgery may delay healing

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            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: Excretion in milk unknown; use caution

            Pregnancy Categories

            A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA: Information not available.

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            Pharmacology

            Mechanism of Action

            Loteprednol: Prevents/reduces irritation & swelling by suppressing normal immune response, decreasing inflammatory mediators and reverses capillary permeability

            Tobramycin: Alters bacterial cell membrane integrity by binding to 30S and 50S ribosomal subunits, which in turn interferes with bacterial protein synthesis

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            Formulary

            FormularyPatient Discounts

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            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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            Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.