Dosing & Uses
AdultPediatric
Diabetes Mellitus Type I
Pending FDA approval for adults with type I diabetes mellitus in combination with insulin therapy
Safety and efficacy not established
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Pharmacology
Mechanism of Action
Dual inhibitor of selective sodium-glucose transporters 1 and 2 (SGLT-1, SGLT-2)
SGLT1 inhibition improves glucose homeostasis by reducing dietary glucose absorption in the intestine and by increasing the release of gastrointestinal incretins (eg, glucagon-like peptide-1 [GLP-1] agonists)
SGLT2 is expressed in the proximal renal tubules and is responsible for the majority of the reabsorption of filtered glucose from the tubular lumen; SGLT2 inhibitors reduce glucose reabsorption and lower the renal threshold for glucose, thereby increasing urinary glucose excretion
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Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.
