Autosomal Dominant Polycystic Kidney Disease

Neera K. Dahl, MD, PhD


May 13, 2020

Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disorder in which clusters of cysts develop within the kidneys. Although benign, these cysts over time can cause kidney enlargement and loss of renal function. Eventually, approximately half of patients will progress to end-stage renal disease by the age of 60.

Complications of ADPKD commonly include cyst rupture or infection, nephrolithiasis, hematuria, intracranial aneurysm, and chronic pain. End-stage renal disease due to ADPKD is a common indication for kidney transplant.

Dr Neera K. Dahl, from the Yale University School of Medicine, discusses the genetic mutations behind ADPKD and disease recognition, as well as treatment strategies for both slow and rapidly progressing disease, including lifestyle modification and medical therapy.


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