Strategies to Prevent Acute Kidney Transplant Rejection

Sundaram Hariharan, MD


December 20, 2021

Patients with end-stage renal disease who receive a kidney transplant have higher survival outcomes compared with those on long-term dialysis therapy. Still, approximately one third of transplant recipients have acute kidney rejection after transplant despite improved immunosuppressive treatments.

In this ReCAP, Dr Sundaram Hariharan of the University of Pittsburgh Medical Center discusses pre- and post-transplantation strategies to decrease the rates of acute rejection and increase long-term survival.

Dr Hariharan explains criteria used for optimal organ selection for a transplant patient, whether using a living or deceased donor. These criteria include pretransplant HLA-DR, eplet, virtual cross-matching techniques, and methods for pairing incompatible or high-risk recipients.

He also summarizes effective clinical and behavioral post-transplant tools and optimization strategies that are critical for preventing transplant rejection and supporting long-term patient survival.


Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.