Slowing Progression of Autosomal Dominant Polycystic Kidney Disease

Anjay Rastogi, MD, PhD


February 25, 2022

Autosomal dominant polycystic kidney disease (ADPKD) is a rare, hereditary disorder that is characterized by the silent, progressive growth of multiple bilateral renal cysts. ADPKD may also affect numerous other organs, including the liver, pancreas, and brain.

There are two types of ADPKD, each determined by the location of a specific chromosomal mutation. Type 1 is the result of a mutation on chromosome 16 and accounts for 80%-85% of ADPKD cases. It is also the more aggressive type and may cause patients to develop renal insufficiency as early as the fourth or fifth decade of life. These patients may require urgent dialysis and kidney transplantation.

Dr Anjay Rastogi, clinical chief of nephrology at University of California, Los Angeles reports on strategies to slow the progression of ADPKD, including lifestyle modifications, management of complications, and disease-specific therapy.


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