Biologic Therapies in Refractory Chronic Rhinosinusitis With Nasal Polyps

Wytske Fokkens, MD, PhD


July 06, 2022

The treatment of chronic rhinosinusitis with nasal polyps (CRSwNP) is typically centered on controlling tissue inflammation by the use of intranasal corticosteroids, nasal saline irrigation, antibiotics, and short courses of oral steroids.

Patients who are refractory to these treatments may undergo surgery, but surgical intervention may offer lasting benefit in only a small proportion of patients.

Prof Wytske Fokkens, from Amsterdam Medical University, describes the effect CRSwNP has on daily living and how inadequately controlled inflammation can result in persistent, bothersome symptoms.

She goes on to examine biologic therapies for CRSwNP and discusses the proposed criteria for identifying patients with severe, uncontrolled disease who may benefit from these treatments.

Prof Fokkens explains that, when the criteria are applied, biologic treatment is effective in over 95% of patients.


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