Fast Five Quiz: Do You Know the Current Guidelines for the Screening and Treatment of Prostate Cancer?

Tan Winston, MD; Bradley Schwartz, DO


April 18, 2022

Prostate cancer grading has traditionally been performed according to the Gleason Grading system, which is on the basis of histologic evaluation of tumor biopsy specimens. It is a two-number system in which the first number is assigned to the predominant focus of tumor and the second assigned to the second more predominant pattern; each is graded on a scale of 1-5, and the sum of the two constitutes the overall grade. Generally, the cutoff for prostate cancer starts with Gleason grade 3 + 3 cancer.

The significance of the Gleason score is as follows:

  • A score of 2-6 indicates a low-grade or well-differentiated tumor

  • A score of 7 indicates a moderate-grade or moderately differentiated tumor

  • A score of 8-10 indicates a high-grade or poorly differentiated tumor

Learn more about the workup for prostate cancer.


Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.