Signs of the accelerated phase of CML include worsening control of blood counts, increasing peripheral blood blast count, basophilia, thrombocytopenia (not related to therapy), new chromosomal abnormalities, myelofibrosis, and increasing splenomegaly.
To read more about the workup of CML, click here.
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Cite this: Fast Five Quiz: How Prepared Are You to Address Chronic Myelogenous Leukemia? - Medscape - Nov 11, 2014.