Much work in the past decade has focused on the development of serologic markers for IBD. ANCA and ASCA have been the most intensely studied.
ANCA is most commonly associated with ulcerative colitis. Specifically, perinuclear ANCA (pANCA), found on the inside of the nuclear membrane, is highly associated with ulcerative colitis. ANCA assay results are positive in 60%-80% of patients with ulcerative colitis.
ASCA is more highly associated with Crohn's disease and is present in 60% of cases. OmpC and anti-I2 have been found in approximately 50% of patients with Crohn's disease and are not associated with ulcerative colitis.
Learn more about ulcerative colitis.
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Cite this: Marc D. Basson, Leyla Ghazi. Fast Five Quiz: Can You Properly Identify Ulcerative Colitis and Initiate Best Treatment? - Medscape - Feb 08, 2023.