Fast Five Quiz: Can You Identify Psoriatic Arthritis and Initiate the Best Treatment Practices?

Herbert S Diamond, MD; Anwar Al Hammadi, MD; Eric M. Ruderman, MD


December 23, 2021

Extra-articular features are observed less frequently in patients with PsA than in those with rheumatoid arthritis (RA); nonetheless, ocular complications are common in patients with PsA. Approximately one third of patients with psoriatic arthritis may experience ocular comorbidities, including notably high incidence rates of uveitis, as well as conjunctivitis in 20% of patients. In the setting of psoriatic arthritis, the presence of HLA-B27 is associated with the development of sacroiliitis. Scleritis and keratoconjunctivitis sicca may occur, but they are rare. Possible ocular findings also include iritis.

Subcutaneous nodules are rare in patients with PsA. If nodules are present in a patient who has psoriasis and arthritis, particularly if the rheumatoid factor titer is positive, they suggest the coincidental occurrence of psoriasis and RA.

Inflammation of the aortic valve root, or aortitis, which may lead to insufficiency, has been described in a small number of patients with PsA and is similar to that observed more frequently in persons with ankylosing spondylitis or reactive arthritis. Although rare, patients with PsA may develop secondary amyloidosis.

Learn more about extra-articular features in PsA.


Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.