Fast Five Quiz: Can You Identify Psoriatic Arthritis and Initiate the Best Treatment Practices?

Herbert S Diamond, MD; Anwar Al Hammadi, MD; Eric M. Ruderman, MD


December 23, 2021

There are no laboratory tests that are specific for PsA. Acute phase reactants such as elevated erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) may become elevated, as they do in most inflammatory diseases, and are markers of severe disease. Patients with PsA typically have lower levels of ESR and CRP than patients with RA. However, a normal ESR and CRP should not be used to rule out a diagnosis of PsA.

Patients with PsA are typically seronegative for rheumatoid factor, although it is detected in 5%-9% of patients. Rheumatoid factor testing is usually associated with a high false-positive rate; thus, patients with positive and negative findings should undergo the same treatment.

Serum immunoglobulin A levels are increased in two thirds of patients with PsA and in one third of patients with psoriasis.

Learn more about the workup for PsA.


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