Fast Five Quiz: Do You Know What to Watch for and How Best to Treat Diabetic Foot Ulcers?

Vincent Lopez Rowe, MD

Disclosures

December 15, 2014

Diabetic peripheral neuropathy (DPN), present in 60% of diabetic persons and 80% of diabetic persons with foot ulcers, confers the greatest risk for foot ulceration; microvascular disease and suboptimal glycemic control contribute.

The pathophysiology of DPN is multifactorial and is thought to result from vascular disease occluding the vasa nervorum; endothelial dysfunction; deficiency of myoinositol-altering myelin synthesis and diminishing sodium-potassium adenine triphosphatase (ATPase) activity; chronic hyperosmolarity, causing edema of nerve trunks; and effects of increased sorbitol and fructose. Other etiologies of diabetic ulceration include arterial disease, pressure, and foot deformity.

For more on the pathophysiology of diabetic ulcers, read here.

Comments

3090D553-9492-4563-8681-AD288FA52ACE
Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.
Post as:

processing....