Ethanol is rapidly absorbed across both the gastric mucosa and the small intestine, reaching a peak concentration 20-60 minutes after ingestion. Once absorbed, it is converted to acetaldehyde. This conversion involves three discrete enzymes: the microsomal cytochrome P450 isoenzyme CYP2E1, the cytosol-based enzyme alcohol dehydrogenase (ADH), and the peroxisome catalase system. Acetaldehyde is then converted to acetate, which is converted to acetyl Co A and ultimately carbon dioxide and water.
For more on the pathophysiology of ethanol alcohol poisoning, read here.
Medscape © 2014
Cite this: Michael D. Levine. Fast Five Quiz: Do You Know the Signs of and Best Treatment for Alcohol Poisoning? - Medscape - Dec 19, 2014.