Both insulin resistance and insufficient insulin secretion contribute to the complex pathophysiology resulting from a diabetogenic lifestyle (excessive caloric intake, inadequate caloric expenditure, and obesity), and genetic factors result in insulin resistance and inadequate insulin secretion. Furthermore, both insulin resistance and inadequate insulin secretion must exist for type 2 diabetes to occur. For example, all overweight individuals have insulin resistance, but type 2 diabetes develops only in those who cannot increase insulin secretion enough to offset their insulin resistance. In such individuals, insulin concentrations may be high, yet they are still inappropriately low for the level of glycemia, per the ADA.
Learn more about the pathogenesis and pathophysiology of type 2 diabetes.
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Cite this: Romesh Khardori, Anne L. Peters. Fast Five Quiz: How Well Do You Know the Risk Factors and Treatment Indications for Type 2 Diabetes? - Medscape - Dec 19, 2022.