Fast Five Quiz: How Well Do You Know the Risk Factors and Treatment Indications for Type 2 Diabetes Mellitus?

Romesh Khardori, MD, PhD


January 30, 2020

The major risk factors for developing type 2 DM include:

  • Age older than 45 years

  • Weight > 120% of desirable body weight

  • Family history of type 2 DM in a first-degree relative (eg, parent or sibling)

  • Being of Hispanic, Native American, non-Hispanic black (ie, African), Asian American, or Pacific Islander descent

  • History of previous impaired glucose tolerance (IGT) or impaired fasting glucose (IFG)

  • Hypertension (blood pressure [BP] > 140/90 mm Hg) or dyslipidemia (high-density lipoprotein cholesterol [HDL-C] level < 40 mg/dL or triglyceride [TG] level > 150 mg/dL)

  • History of gestational DM or of delivering a baby weighing over 9 lb (4.08 kg)

  • Polycystic ovary syndrome

While a subset of patients may present with lean diabetes, being underweight with fluctuating serum glucose levels is not a risk factor for developing type 2 DM.

Prehypertension and hypertension increase a patient's risk of developing type 2 DM, particularly in white patients.

Patients who have first- and second-degree relatives with type 2 DM are at increased risk of developing the disease; having third-degree relatives with type 2 DM is not considered a major risk factor for developing diabetes.

Learn more about major risk factors for type 2 DM.


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