Fast Five Quiz: How Much Do You Know About HIV?

Michael Stuart Bronze, MD; Nicholas J. Bennett, MBBCh, PhD, MA(Cantab)


May 10, 2021

According to the HHS guidelines, an ARV regimen for a treatment-naive patient generally consists of a dual NRTI regimen administered in combination with a third active ARV drug from one of three drug classes: an INSTI, a NNRTI, or a PI with a PK enhancer. The use of the INSTI dolutegravir, plus the NRTI lamivudine, is also recommended in certain patient populations (see below). Recommended initial regimens include:

  • Bictegravir/tenofovir alafenamide/emtricitabine

  • Dolutegravir/abacavir/lamivudine — only for individuals who are HLA-B*5701 negative and without chronic hepatitis B virus (HBV) coinfection

  • Dolutegravir plus (emtricitabine or lamivudine) plus (tenofovir alafenamide or tenofovir disoproxil fumarate)

  • Dolutegravir/lamivudine — except for individuals with HIV RNA > 500,000 copies/mL, HBV co-infection, or in whom ART is to be started before the results of HIV genotypic resistance testing for reverse transcriptase or HBV testing are available

  • Raltegravir plus (emtricitabine or lamivudine) plus (tenofovir alafenamide [TAF] or tenofovir disoproxil fumarate [TDF])

For additional information, refer to the HHS Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents Living with HIV.

Learn more about HIV treatment approaches.


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