An ARV regimen for a patient who is treatment-naive generally consists of a dual NRTI regimen administered in combination with a third active ARV drug from one of three drug classes: an INSTI, an NNRTI or a PI with a PK enhancer.
When choosing between an INSTI, PI or NNRTI in an initial ARV regimen, there are several factors that should be considered. These include drug efficacy, barrier to resistance, possible adverse effects, drug interactions, convenience, the patient’s comorbidities and associated medications and whether the individual has been given long-acting cabotegravir as preexposure prophylaxis.
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Cite this: Michael Stuart Bronze, Nicholas J. Bennett. Fast Five Quiz: How Much Do You Know About HIV? - Medscape - Jun 01, 2023.