Abnormal humoral immunity and leukopenia may lead to lead to infection. Pneumococcal organisms are commonly involved, but shingles (ie, herpes zoster) and Haemophilus infections are also more common among patients with multiple myeloma.
Hyperviscosity may be associated with a number of symptoms, including generalized malaise, infection, fever, paresthesia, sluggish mentation, and sensory loss. Patients may report headaches and somnolence, and they may bruise easily and have hazy vision. Patients with multiple myeloma typically experience these symptoms when their serum viscosity is greater than four times that of normal serum. However, hyperviscosity is a rare complication of multiple myeloma and is more commonly seen in lymphoproliferative disorders such as Waldenstrom macroglobulinemia, which is associated with immunoglobulin M gammopathy.
Learn more about the presentation of multiple myeloma.
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Cite this: Emmanuel C Besa, Dhaval Shah. Fast Five Quiz: Are You Prepared to Confront Multiple Myeloma? - Medscape - Jan 14, 2022.