The most specific antibody for SLE is the anti-Smith antibody; however, the sensitivity is only 30%-40%. Antinuclear antibody (ANA) is used for screening and has a sensitivity of 95%. Anti-Ro antibodies are present in 15% of patients with SLE and other connective tissue diseases. Anti-dsDNA antibodies have a high specificity, but a sensitivity of only 70%. Drug-induced lupus ANA antibodies are usually antihistone.
For more on the workup of SLE, read here.
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Cite this: Herbert S. Diamond. Fast Five Quiz: How Much Do You Know About Systemic Lupus Erythematosus? - Medscape - Nov 03, 2015.