The primary risk factor for C difficile colitis is previous exposure to antibiotics; the most commonly implicated agents include the cephalosporins (especially second- and third-generation), the fluoroquinolones, ampicillin/amoxicillin, and clindamycin. Less commonly implicated antibiotics are the macrolides (ie, erythromycin, clarithromycin, azithromycin) and other penicillins. Agents occasionally reported to cause the disease include aminoglycosides, trimethoprim/sulfamethoxazole, metronidazole, chloramphenicol, tetracycline, imipenem, and meropenem.
For more on the background of C difficile infection, read here.
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Cite this: Michael Stuart Bronze. Fast Five Quiz: Are You Able to Confront Clostridium Difficile Infections? - Medscape - Jan 04, 2016.