CT is the imaging modality of choice for C difficile colitis when pseudomembranous colitis, other complications of C difficile infection, or other intra-abdominal pathology is suspected. Marked colonic wall thickening is the most common finding. Other features may include ascites, irregularity of the bowel wall, and pericolonic stranding.
In patients with sepsis due to suspected megacolon, abdominal radiography may be performed instead of CT to establish the presence of megacolon in a timely manner.
For more on the workup of C difficile infection, read here.
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Cite this: Michael Stuart Bronze. Fast Five Quiz: Are You Able to Confront Clostridium Difficile Infections? - Medscape - Jan 04, 2016.