To avoid ODS in patients with chronic hyponatremia (known duration >48 hours), the recommendations include the following:
Minimum correction of serum sodium by 4-8 mmol/L per day, with a lower goal of 4-6 mmol/L per day if the risk for ODS is high
For patients at high risk for ODS: maximum correction of 8 mmol/L in any 24-hour period
For patients at normal risk for ODS: maximum correction of 10-12 mmol/L in any 24-hour period and 18 mmol/L in any 48-hour period
For more on hyponatremia treatment, read here.
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Cite this: Romesh Khardori. Fast Five Quiz: What Do You Know About Hyponatremia? - Medscape - Apr 19, 2016.
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