Fast Five Quiz: How Much Do You Know About Chronic Myelogenous Leukemia?

Emmanuel C. Besa, MD


August 15, 2016

Poor-prognosis characteristics include the following clinical and laboratory factors:

  • Older age

  • Symptomatic presentation

  • Poor performance status

  • African American descent

  • Hepatomegaly

  • Splenomegaly

  • Negative Ph chromosome or BCR/ABL

  • Anemia

  • Thrombocytopenia

  • Thrombocytosis

  • Decreased megakaryocytes

  • Basophilia

  • Myelofibrosis (increased reticulin or collagen)

Approximately 85% of cases are diagnosed in the chronic phase and then progress to the accelerated and blast phases after 3-5 years. CML accounts for 20% of all leukemias affecting adults. It typically affects middle-aged persons. The American Cancer Society estimates that 8220 new cases of CML will be diagnosed in 2016: 4610 in males and 3610 in females.

For more on the background of CML, read here.


Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.