Recommendations for the treatment of moderate to severe plaque psoriasis include the following:
Methotrexate may be used for as long as it remains effective and well tolerated.
Cyclosporine is generally used intermittently for inducing a clinical response with one or several courses over a 3- to 6-month period.
Transition from conventional systemic therapy to a biologic agent may be done directly or with an overlap if transitioning is needed because of lack of efficacy, or with a treatment-free interval if transitioning is needed for safety reasons.
Combination therapy may be helpful.
Continuous therapy for patients receiving biologics is recommended.
Switching biologics because of lack of efficacy should be performed without a washout period, while switching biologics for safety reasons may require a treatment-free interval.
For more on the treatment of psoriasis, read here.
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Cite this: Dirk M Elston, William James. Fast Five Quiz: What Do You Know About Psoriasis? - Medscape - Jun 13, 2019.
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