Fast Five Quiz: How Much Do You Know About Facilitating Healthy Weight Loss?

Romesh Khardori, MD, PhD; Evelyn S. Marienberg, MD


November 06, 2023

Low-fat, high-carbohydrate diets have been associated with:

  • Lower increases in high-density lipoprotein cholesterol (HDL-C)

  • Lower reduction in serum triglycerides

  • Higher reduction in low-density lipoprotein cholesterol

  • Similar weight loss at 6-12 months with calorie restriction

However, other trials have demonstrated that low-carbohydrate, high-fat diets were associated with a greater effect on weight loss and HDL-C changes than low-fat, high-carbohydrate diets.

As previously stated, the first-line intervention is usually a combination of nutrition, physical activity, and behavior change support, not just diet, and should be based on the health of the individual.

Learn more about evidence-based strategies for facilitating weight loss.


Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.