Psychiatry Fast Five Quiz: How Much Do You Know About Premature Ejaculation?

Stephen Soreff, MD


December 28, 2016

No drug is specifically approved by the US Food and Drug Administration for the treatment of premature ejaculation, but various agents can be used safely and effectively for this purpose.

SSRIs (eg, sertraline, paroxetine, fluoxetine, citalopram, dapoxetine) and agents with SSRI-like effects have proven to be the most successful agents in treating premature ejaculation, but the effects of long-term use are a concern.

The PDE5 inhibitors sildenafil and tadalafil have been shown to be safe and effective treatment adjuncts. In some studies, PDE5 inhibitors in combination with SSRIs have produced better results than SSRIs alone. The TCA clomipramine may be more effective than many SSRIs for premature ejaculation. It is hypothesized that the beta-adrenergic blocker pindolol may potentiate the action of SSRIs, but more studies are needed before pindolol, used alone, can be considered as a first-line treatment.

For more on the use of medications in treating premature ejaculation, read here.

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