Patients with iodine deficiency tend to come from regions where iodine deficiency disorders are endemic. The first sign of iodine deficiency is diffuse thyroid enlargement, which becomes multinodular over time. In patients with hypothyroidism due to severe iodine deficiency, one might see such signs as dry skin, periorbital edema, and delayed relaxation phase of the deep tendon reflexes.
For more on iodine deficiency, read here.
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Cite this: Romesh Khardori. Fast Five Quiz: Test Yourself on Various Nutritional Deficiencies - Medscape - Apr 10, 2017.