Fast Five Quiz: How Much Do You Know About Typhoid Fever?

Michael Stuart Bronze, MD

Disclosures

April 13, 2017

Paratyphi is more common among newcomers to urban areas, probably because they tend to be immunologically naive to it. Also, travelers get little or no protection against paratyphi from the current typhoid vaccines, all of which target typhi.

Typhoidal salmonella have no nonhuman vectors. An inoculum as small as 100,000 organisms of typhi causes infection in more than 50% of healthy volunteers. Paratyphi requires a much higher inoculum to infect, and it is less endemic in rural areas. Hence, the patterns of transmission are slightly different.

Other risk factors for typhoid fever include various genetic polymorphisms. These risk factors often also predispose to other intracellular pathogens.

For more on the risk factors for typhoid fever, read here.

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