Fast Five Quiz: How Much Do You Know About Typhoid Fever?

Michael Stuart Bronze, MD

Disclosures

April 13, 2017

Mild hyponatremia and hypokalemia are common in patients with typhoid fever. Most patients with typhoid fever also have a slightly elevated prothrombin time and activated partial thromboplastin time and decreased fibrinogen levels.

Assays that identify Salmonella antibodies or antigens support the diagnosis of typhoid fever, but these results should be confirmed with cultures or DNA evidence. The Widal test was the mainstay of typhoid fever diagnosis for decades. It is used to measure agglutinating antibodies against H and O antigens of S typhi. Neither sensitive nor specific, the Widal test is no longer an acceptable clinical method.

For more on the workup of typhoid fever, read here.

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