Fast Five Quiz: Test Your Knowledge of Mantle Cell Lymphoma

Elwyn C Cabebe, MD; Winston W. Tan, MD; Ann S. LaCasce, MD, MMSc


January 09, 2023

Figure 1. Patient with affected lymph node.

Stage III or IV disease is present in 70%-80% of MCL cases at presentation.

Findings on the history may include:

  • B symptoms, which include fever, night sweats, and weight loss, in 40% of patients

  • Generalized lymphadenopathy

  • Abdominal distention from hepatosplenomegaly

  • Fatigue from anemia or bulky disease

  • Less common symptoms caused by extranodal involvement of gastrointestinal tract and lungs

Physical examination findings may include:

  • Generalized lymphadenopathy in 90%

  • Splenomegaly in 60% (may be massive)

  • Hepatomegaly in 30%

  • Poor performance status in 20%

  • Gastrointestinal tract involvement in 26%

  • CNS involvement (though rare)

Learn more about MCL.


Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.