Fast Five Quiz: Test Your Knowledge of Mantle Cell Lymphoma

Elwyn C Cabebe, MD; Winston W. Tan, MD; Ann S. LaCasce, MD, MMSc


January 09, 2023

Both LDH and Ki-67 percentage are prognostic indicators and are included in established risk-stratification models. Elevated LDH levels correlate with tumor burden, and Ki-67 percentage greater than 30% is associated with higher-risk disease.

In addition, blood studies may also yield the following results in MCL:

  • Complete blood count: Anemia and cytopenias are secondary to bone marrow infiltration; lymphocytosis of > 4000/µL occurs in 20%-40% of cases.

  • Serum chemistry: Elevation of lactate dehydrogenase levels correlates with tumor burden.

  • Liver function tests: Abnormal findings result from liver involvement.

  • Gamma globulin: Hypogammaglobulinemia and monoclonal gammopathy are rare findings.

  • Coombs test: Results are rarely positive.

Learn more about the workup of MCL.


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