Both LDH and Ki-67 percentage are prognostic indicators and are included in established risk-stratification models. Elevated LDH levels correlate with tumor burden, and Ki-67 percentage greater than 30% is associated with higher-risk disease.
In addition, blood studies may also yield the following results in MCL:
Complete blood count: Anemia and cytopenias are secondary to bone marrow infiltration; lymphocytosis of > 4000/µL occurs in 20%-40% of cases.
Serum chemistry: Elevation of lactate dehydrogenase levels correlates with tumor burden.
Liver function tests: Abnormal findings result from liver involvement.
Gamma globulin: Hypogammaglobulinemia and monoclonal gammopathy are rare findings.
Coombs test: Results are rarely positive.
Learn more about the workup of MCL.
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Cite this: Elwyn C Cabebe, Winston W. Tan, Ann S. LaCasce. Fast Five Quiz: Test Your Knowledge of Mantle Cell Lymphoma - Medscape - Jan 09, 2023.