Common signs of thyrotoxicosis include the following:
Tachycardia or atrial arrhythmia
Systolic hypertension with wide pulse pressure
Warm, moist, smooth skin
Weight loss despite increased appetite (although a few patients may gain weight if excessive intake outstrips weight loss)
Reduction in menstrual flow or oligomenorrhea
If the thyroid is enlarged and painful, subacute painful or granulomatous thyroiditis is the likely diagnosis. However, degeneration or hemorrhage into a nodule and suppurative thyroiditis should also be considered.
Toxic multinodular goiters generally occur when the thyroid gland is enlarged to at least two to three times the normal size. The gland often is soft, but individual nodules occasionally can be palpated.
In rare instances, Graves disease affects the skin through deposition of glycosaminoglycans in the dermis of the lower leg. This causes nonpitting edema, which is usually associated with erythema and thickening of the skin, without pain or pruritus.
For more on the physical examination findings in hyperthyroidism and thyrotoxicosis, read here.
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Cite this: Romesh Khardori. Fast Five Quiz: How Much Do You Know About Hyperthyroidism? - Medscape - May 08, 2017.