A 49-Year-Old Man With Forgetfulness and Gait Impairment

Sumaira Nabi, MBBS, FCPS; Sadaf Fayyaz, MBBS; Shahzad Ahmed, MBBS


June 27, 2017

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A 49-year-old man presents with a 1-year history of progressive memory loss and forgetfulness. His wife also describes progressive gait impairment; brief, repetitive, generalized jerky movements, with clumsiness using his arms; slurring of speech; and emotional lability for 6 months. He depends on caregivers for most activities of daily living. At times, he wanders off and cannot find his way back to his room.

He has no history of fever, loss of consciousness, visual loss, sphincter dysfunction, or sensory symptoms. He is a nonsmoker and denies substance abuse. He has no history of travel abroad or extramarital relationships. His medical and surgical history are unremarkable, and his family history is noncontributory.


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