Fast Five Quiz: How Much Do You Know About Nephrotic Syndrome?

Vecihi Batuman, MD

Disclosures

July 19, 2017

Nephrotic syndrome can be primary (a disease specific to the kidneys) or secondary (a renal manifestation of a systemic general illness). In all cases, injury to glomeruli is an essential feature. Kidney diseases that affect tubules and interstitium, such as interstitial nephritis, do not cause nephrotic syndrome.

Primary causes of nephrotic syndrome include the following, in approximate order of frequency:

  • Minimal-change nephropathy

  • Focal glomerulosclerosis

  • Membranous nephropathy

  • Hereditary nephropathies

Secondary causes include the following, again in order of approximate frequency:

  • Diabetes mellitus

  • Lupus erythematosus

  • Viral infections (eg, hepatitis B, hepatitis C, HIV)

  • Amyloidosis and paraproteinemias

  • Preeclampsia

  • Alloantibodies from enzyme replacement therapy

For more on the etiology of nephrotic syndrome, read here.

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