Clinical Trends for November 2017

Ryan Syrek

Disclosures

December 01, 2017

Clinical Trend of the Week (November 11-17): Alagille Syndrome

Promising research involving a rare condition resulted in this week's top search term. Alagille syndrome is a genetic disorder that is characterized by liver damage that involves the bile ducts. Findings from a phase 2 study that evaluated the efficacy and safety of an apical sodium-dependent bile acid transporter inhibitor used to treat Alagille syndrome were recently presented at The Liver Meeting 2017: American Association for the Study of Liver Diseases. Separate research using zebrafish identified tissues and genes that are crucial to liver duct development; further investigations will explore potential regenerative therapies designed to restore function and possibly prevent the need for liver transplant in some patients with Alagille syndrome. Although both sets of findings are preliminary, optimism for future treatments and therapy for this rare condition resulted in this week's top search term.

For more information on Alagille syndrome, read here

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