Bleeding is the most frequently cited sign. Malaise and fatigue are probably due to anemia, which often is present in patients who bleed chronically. These tumors sometimes necrose and bleed into the bowel.
Leiomyosarcomas are most commonly found within the extremities, although they may be found throughout the body, including the retroperitoneum, large vascular structures, and the uterus. A mass rarely is palpable. Weight loss is reported as a late feature, with an incidence of around 20%. Cachexia, hepatomegaly, and ascites may be present in patients with advanced metastatic disease.
For more on the presentation of intestinal leiomyosarcoma, read here.
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Cite this: Fast Five Quiz: Test Your Knowledge of Soft-Tissue Sarcomas - Medscape - Jan 03, 2018.