Fast Five Quiz: Test Your Knowledge of Caffeine Consumption, Toxicity, and Overdose

Richard H. Sinert, DO

Disclosures

January 26, 2018

Certain medications, such as CYP inhibitors (eg, cimetidine) and oral contraceptives, impair caffeine metabolism. Caffeine clearance is reduced in patients with chronic liver disease, in pregnant women, and in infants. Caffeine clearance is increased in smokers. With smoking cessation, serum caffeine concentrations can double even if caffeine consumption remains stable. Oral doses of caffeine >10 g can be fatal in adults. A daily intake of 400 mg—about 4 or 5 cups of coffee—is considered safe for adults, while 200 mg is considered safe for pregnant women.

For more on caffeine toxicity, read here.

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