The diagnostic criteria set by the PVSG are organized into two categories, A and B. The diagnosis of PV is established if all three category A criteria are present, or if criteria A1 plus A2 plus any two criteria from category B are present.
Category A criteria are as follows:
Total red blood cell mass ≥ 36 mL/kg in males or ≥ 32 mL/kg in females
Arterial oxygen saturation ≥ 92%
Splenomegaly
Category B criteria are as follows:
Total red blood cell mass ≥ 36 mL/kg in males or ≥ 32 mL/kg in females
Arterial oxygen saturation ≥ 92%
Splenomegaly
Thrombocytosis, with platelet count > 400,000/μL
Leukocytosis, with a white blood cell count > 12,000/μL
Increased leukocyte alkaline phosphatase > 100 U/L
Serum vitamin B12 concentration > 900 pg/mL or binding capacity > 2200 pg/mL
For more on the workup of PV, read here.
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Cite this: Emmanuel C. Besa. Fast Five Quiz: Are You Familiar With Key Aspects of Polycythemia Vera? - Medscape - Apr 04, 2018.
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