Diagnostic criteria for PV as per the 2016 revised WHO guidelines include three major criteria and a minor criterion. Diagnosis requires the presence of either all three major criteria or the first two major criteria and the minor criterion.
Major WHO criteria are as follows:
Hemoglobin > 16.5 g/dL in men and > 16 g/dL in women, or hematocrit > 49% in men and > 48% in women, or red cell mass > 25% above mean normal predicted value
Bone marrow biopsy showing hypercellularity for age with trilineage growth (panmyelosis) including prominent erythroid, granulocytic, and megakaryocytic proliferation with pleomorphic, mature megakaryocytes (differences in size)
Presence of JAK2 V617F or JAK2 exon 12 mutation
The minor WHO criterion is as follows:
Serum erythropoietin level below the reference range for normal
For more on diagnostic criteria for PV, read here.
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Cite this: Emmanuel C. Besa. Fast Five Quiz: Are You Familiar With Key Aspects of Polycythemia Vera? - Medscape - Apr 04, 2018.