Pain at sites of nodal disease precipitated by drinking alcohol occurs in fewer than 10% of patients but is specific for Hodgkin lymphoma.
In nodular sclerosing Hodgkin lymphoma, which constitutes 60%-80% of all cases of Hodgkin lymphoma, the morphology shows a nodular pattern. In mixed-cellularity Hodgkin lymphoma, which constitutes 15%-30% of cases, the infiltrate is usually diffuse. Reed-Sternberg cells are of the classical type (large, with bilobate, double or multiple nuclei and a large, eosinophilic nucleolus).
Lactate dehydrogenase may be increased. Lactate dehydrogenase levels may correlate with the bulk of disease. Serum creatinine may be elevated in the rare cases of nephrotic syndrome associated with Hodgkin lymphoma.
Formerly, staging laparotomy and laparoscopy were the standard of care in Hodgkin lymphoma, but with modern imaging and treatment paradigms these procedures are no longer needed.
For more on Hodgkin lymphoma, read here.
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Cite this: Elwyn C. Cabebe. Fast Five Quiz: Can You Identify and Properly Treat Worrisome Neck Masses? - Medscape - May 01, 2018.