Physical Examination and Workup
Upon physical examination, a review of systems is negative for fevers, rashes, fatigue, seizures, jaundice, vomiting, diarrhea, behavioral changes, easy bruising, and musculoskeletal or visual disturbances.
His weight is 53.5 lb (24.25 kg), which puts him beneath the fifth percentile for his age. His height is 4'1" (125 cm), which also is beneath the fifth percentile for his age. A head, eyes, ears, nose, and throat examination reveals anicteric, moist pink conjunctiva and shoddy mobile anterior cervical lymphadenopathy (largest, <1 cm). He has no rash, edema, joint swelling, warmth, or tenderness.
His lungs are clear to auscultation. Bilateral breath sounds are equal. His abdomen is soft and distended, with normal bowel sounds. His liver is 3 cm below the right costal margin. It is smooth, nontender, and not firm. His spleen is palpable 10 cm below the left costal margin and is 6 cm wide. It is nontender. No other tenderness or peritoneal signs are noted.
Laboratory findings are as follows:
White blood cell (WBC) count—5.7 x 109/L
Hemoglobin level—9.7 g/dL (hemoglobin electrophoresis is normal)
Mean corpuscular volume—77.5 fL/red cell
Platelet count—128 x 109/L
Comprehensive metabolic panel results are as follows:
Sodium level—138 mEq/L
Potassium level—3.7 mEq/L
Chloride level—103 mEq/L
Carbon dioxide level—27 mEq/L
Glucose level—101 mmol/L
Blood urea nitrogen level—9 mmol/L
Creatinine level—0.34 mg/dL
Total protein level—7.9 g/dL
Albumin level—4.5 g/L
Calcium level—10.2 mg/dL
Total bilirubin level—1.9 mg/dL
Direct bilirubin level—0.3 mg/dL
Alkaline phosphatase level—206 IU/L
Aspartate aminotransferase level—26 IU/L
Alanine aminotransferase level—13 IU/L
Urinalysis reveals clear urine with a trace of blood. It is negative for urobilinogen, nitrate, leukocyte esterase, glucose, and ketones. Occasional bacteria is noted, with no other organisms seen. A urine culture reveals no growth. Other urinalysis findings are as follows:
Protein level—100 mg/dL
Red blood cell (RBC) count—9 RBC/high-powered field (HPF)
WBC count—40 WBC/HPF
Stool tests negative for the presence of blood. An immune and metabolic workup is negative for antinuclear antibody and rheumatoid factor. Ferritin level is normal, as is the urine glycosaminoglycan level. A T-cell subset panel reveals normal findings. Other findings are as follows:
Erythrocyte sedimentation rate—55 mm/hr
C-reactive protein level—<4 mg/L
Lactate dehydrogenase level—245 IU/L
Immunoglobulin (Ig) M level—156 mg/dL
IgG level—2053 mg/dL
IgA level—75.9 mg/dL
IgE level—355 mg/dL
Further evaluation looked at exposure to infectious agents. The patient's Epstein-Barr virus results are negative. Hepatitis C antibody, hepatitis B surface antigen, and HIV tests are negative. Quantiferon testing for latent tuberculosis is negative. A malaria blood smear is also negative. The patient tests negative to the following organisms:
By abdominal ultrasonography, the patient's liver is 12.1 cm with normal echogenicity, no nodularity, and no intrahepatic or extrahepatic ductal dilatation. The common bile duct is 2.4 mm. No mass is identified. His spleen is 15 cm, with tortuosity and dilatation of the splenic vasculature (Figure).
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Cite this: Rebecca Winderman, Natalie Banniettis, Simon S. Rabinowitz. Chronic Splenomegaly in a 10-Year-Old Boy - Medscape - Apr 23, 2018.