Fast Five Quiz: Key Aspects of Metastatic Breast Cancer

Elwyn C. Cabebe, MD

Disclosures

August 10, 2020

Breast cancer is one of the most common malignancies to spread to the skin. The most likely site for cutaneous metastases in women is the chest; less common sites include the scalp, the neck, the upper extremities, the abdomen, and the back.

The breast, skin, stomach, lungs, uterus, large intestine, and kidneys are the most frequent organs to produce cutaneous metastases. Cutaneous metastases are very rare in children. In most cases, cutaneous metastases develop after the initial diagnosis of the primary malignancy (eg, metastases of breast carcinoma involving the chest wall several years after a mastectomy).

Common cutaneous metastasis sites and their probable primary sites are as follows:

  • Metastasis to scalp: Breast, lung, kidney

  • Metastasis to neck: Oral squamous cell carcinoma

  • Metastasis to face: Oral squamous cell carcinoma, renal cell, lung

  • Metastasis to extremities: Malignant melanoma, breast, lung, renal, intestinal

  • Metastasis to chest: Breast, lung, malignant melanoma

  • Metastasis to abdomen: Colon, lung, stomach, breast, ovary

  • Metastasis to umbilicus: Stomach, pancreas, colon, ovary, kidney, breast

  • Metastasis to pelvis: Colon

  • Metastasis to back: Lung

Learn more about dermatologic manifestations of metastatic carcinomas.

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