Fast Five Quiz: Key Aspects of Metastatic Breast Cancer

Elwyn C. Cabebe, MD


December 02, 2021

Local irradiation should be considered for patients with localized bony disease that is symptomatic or at risk of producing a catastrophic complication (eg, spinal cord compression or pathologic fracture). According to the National Comprehensive Cancer Network (NCCN) Breast Cancer Clinical Practice Guidelines, any of the following may be given (all with calcium and vitamin D supplementation) in conjunction with chemotherapy or endocrine therapy:

  • Denosumab 120 mg subcutaneously every 4 weeks or

  • Zoledronic acid 4 mg intravenously over 15 minutes or

  • Pamidronate 90 mg intravenously over 2 hours

Learn more about bone disease treatment in patients with metastatic breast cancer.


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