Radiation therapy should be considered for patients with bone metastasis in case of symptoms or risk for complications (eg, spinal cord compression or pathologic fracture). According to the NCCN Breast Cancer Clinical Practice Guidelines, any of the following may be given (all with calcium and vitamin D supplementation) in conjunction with chemotherapy or endocrine therapy, if expected survival is at least 3 months and renal function is adequate:
Denosumab 120 mg subcutaneously or
Zoledronic acid 4 mg intravenously over 15 minutes or
Pamidronate 90 mg intravenously over 2 hours
Learn more about bone disease treatment in patients with metastatic breast cancer.
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Cite this: Stefania Morganti. Fast Five Quiz: Key Aspects of Metastatic Breast Cancer - Medscape - Dec 15, 2022.