Local irradiation should be considered for patients with localized bony disease that is symptomatic or at risk of producing a catastrophic complication (eg, spinal cord compression or pathologic fracture). According to the National Comprehensive Cancer Network (NCCN) Breast Cancer Clinical Practice Guidelines, any of the following may be given (all with calcium and vitamin D supplementation) in conjunction with chemotherapy or endocrine therapy:
Denosumab 120 mg subcutaneously every 4 weeks or
Zoledronic acid 4 mg intravenously over 15 minutes or
Pamidronate 90 mg intravenously over 2 hours
Learn more about bone disease treatment in patients with metastatic breast cancer.
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Cite this: Elwyn C. Cabebe. Fast Five Quiz: Key Aspects of Metastatic Breast Cancer - Medscape - Dec 02, 2021.
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