
The most reliable screening measure of thyroid function is the TSH level. TSH levels usually are suppressed to unmeasurable levels (< 0.05 µIU/mL) in thyrotoxicosis. The degree of thyrotoxicosis is determined by measurement of thyroid hormone levels; the severity of clinical manifestations often does not correlate with the degree of thyroid hormone elevation.
The degree of thyrotoxicosis is determined by measurement of thyroid hormone levels; however, the severity of clinical manifestations often does not correlate with the degree of thyroid hormone elevation.
A significant number of healthy people without active thyroid disease have mildly positive anti-TPO antibody titers; thus, the test should not be performed for screening purposes.
The following are RAIU (over neck) findings associated with various forms of thyrotoxicosis and hyperthyroidism:
Diffuse toxic goiter (Graves disease): Increased (moderate to high: 40%-100%)
Toxic multinodular goiter (Plummer disease): Increased (mild to moderate: 25%-60%)
Thyrotoxic phase of subacute thyroiditis: Decreased (very low: < 2%)
Toxic adenoma -: Increased (mild to moderate: 25%-60%)
For more on the workup for hyperthyroidism and thyrotoxicosis, read here.
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Any views expressed above are the author's own and do not necessarily reflect the views of WebMD or Medscape.
Cite this: Romesh Khardori. Fast Five Quiz: Test Yourself on Key Thyroid Conditions - Medscape - Aug 06, 2018.
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