Fast Five Quiz: Test Yourself on Key Thyroid Conditions

Romesh Khardori, MD, PhD

Disclosures

August 06, 2018

The most reliable screening measure of thyroid function is the TSH level. TSH levels usually are suppressed to unmeasurable levels (< 0.05 µIU/mL) in thyrotoxicosis. The degree of thyrotoxicosis is determined by measurement of thyroid hormone levels; the severity of clinical manifestations often does not correlate with the degree of thyroid hormone elevation.

The degree of thyrotoxicosis is determined by measurement of thyroid hormone levels; however, the severity of clinical manifestations often does not correlate with the degree of thyroid hormone elevation.

A significant number of healthy people without active thyroid disease have mildly positive anti-TPO antibody titers; thus, the test should not be performed for screening purposes.

The following are RAIU (over neck) findings associated with various forms of thyrotoxicosis and hyperthyroidism:

  • Diffuse toxic goiter (Graves disease): Increased (moderate to high: 40%-100%)

  • Toxic multinodular goiter (Plummer disease): Increased (mild to moderate: 25%-60%)

  • Thyrotoxic phase of subacute thyroiditis: Decreased (very low: < 2%)

  • Toxic adenoma -: Increased (mild to moderate: 25%-60%)

For more on the workup for hyperthyroidism and thyrotoxicosis, read here.

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