Fast Five Quiz: How Much Do You Know About the Genetics of Breast Cancer?

Maurie Markman, MD


December 29, 2020

Women of Ashkenazi Jewish descent have the highest prevalence of the BRCA1 mutation, at 8.3%. Independent of BRCA status, Ashkenazi Jewish women have double the baseline risk for breast cancer. It is estimated that 2.5% (1:40) of patients of Ashkenazi Jewish descent carry one of the three BRCA1 or BRCA2 founder mutations (185delAG, 538insC in BRCA1; 6174delT in BRCA2). Women who inherit a mutation in the BRCA1 or BRCA2 gene have an estimated 50%-80% lifetime risk of developing breast cancer.

Learn more about the pathophysiology of breast cancer.


Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.