Preventive Migraine Treatment
Consider preventive treatment for migraine patients in any of the following situations:
Migraine attacks are frequent (≥4 migraine headache days per month) and/or the attacks interfere with patients' daily routines even with acute treatment
There is contradiction to, failure, or overuse of acute treatments
Acute treatments lead to adverse events
Oral treatments should be offered for migraine prevention. These include antiepileptic drugs, beta-blockers, and frovatriptan. Do not prescribe valproate sodium and topiramate to women who are not using birth control and who may become pregnant.
Start oral treatments at a low dose and titrate slowly.
Give oral treatments for at least 8 weeks to optimize therapeutic response.
Acute Migraine Treatment
Use evidence-based treatment at the first sign of a migraine attack.
Use NSAIDs (including aspirin), nonopioid analgesics, acetaminophen, or caffeinated analgesic combinations for mild‐to‐moderate attacks and migraine‐specific agents (triptans, dihydroergotamine) for moderate or severe attacks and mild‐to‐moderate attacks that respond poorly to NSAIDs or caffeinated combinations.
Use a nonoral option for select patients, including those with nausea or vomiting or those who have trouble swallowing.
Options for outpatient rescue include SC sumatriptan, DHE injection or intranasal spray, or corticosteroids. Inpatient options may include parenteral formulations of triptans, DHE, antiemetics, NSAIDs, anticonvulsants (eg, valproate sodium and topiramate, except in women of childbearing age who are not using reliable birth control), corticosteroids, and magnesium sulfate.
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Any views expressed above are the author's own and do not necessarily reflect the views of WebMD or Medscape.
Cite this: Migraine Treatment Guidelines (2019) - Medscape - Feb 04, 2019.