The REAL and WHO classifications define WM as a rare, chronic, slowly progressive lymphoplasmacytic lymphoma due to a mutation in B lymphocytes. This mutation causes an overproduction of IgM, resulting in HVS and lymphoplasmacytic infiltrate in the bone marrow.
WM is not a form of chronic obstructive pulmonary disease, chronic lymphocytic leukemia, nor fibroblastic sarcoma.
Learn more about the pathophysiology of WM.
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Cite this: Emmanuel C. Besa. Fast Five Quiz: Can You Diagnose Waldenström Macroglobulinemia? - Medscape - Jun 13, 2023.