Fast Five Quiz: How Much Do You Know About HIV Pre- and Postexposure Prophylaxis?

Jason F. Okulicz, MD


January 19, 2021

Although the US Public Health Service previously advised that ARV prophylaxis decisions should be based on the extent and severity of the exposure, the updated guidelines recommend PEP treatment with three or more ARVs for any type of exposure. Recommended PEP regimens include those that consist of a dual nucleoside/nucleotide reverse transcriptase inhibitor (NRTI) backbone plus an integrase strand transfer inhibitor (INSTI), a ritonavir-boosted protease inhibitor (PI), or a nonnucleoside reverse transcriptase inhibitor (NNRTI).

The US Public Health Service guidelines also provide a list of alternative HIV PEP regimens. These involve one pair of nucleoside/nucleotide reverse transcriptase inhibitors in combination with one drug or drug pair from the protease inhibitor, integrase strand transfer inhibitor, or nonnucleoside reverse transcriptase inhibitor classes.

Learn more about treatment options for patients after an occupation-related HIV exposure.


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