Fast Five Quiz: Metastatic Breast Cancer Signs and Symptoms

Elwyn C. Cabebe, MD; Winston W. Tan, MD, FACP; Stefania Morganti, MD


December 21, 2022

As with breast cancer metastasis to other sites, liver metastasis may or may not produce symptoms. Patients with liver metastasis may have clinical signs of hepatomegaly or ascites.

Other symptoms associated with liver metastasis are:

  • Itching: The itching associated with liver metastasis is caused by bile acid build-up in the skin. This itching may be severe and is commonly reported as one of the more annoying symptoms.

  • Jaundice: The skin or eyes may become yellowed because of extensive liver involvement or blockage of the bile duct

  • Abdominal pain: This is typically felt under the ribs on the right side

  • Shoulder pain: Nerves that travel near the diaphragm may become compressed and cause pain in the right shoulder

  • Hiccups: An enlarged liver may press against the diaphragm and cause hiccups

  • Nausea, loss of appetite, and weight loss

  • Fatigue

  • Fever

  • Swelling of the ankles

Learn more about liver metastasis imaging.


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