Fast Five Quiz: How Much Do You Know About Psoriatic Arthritis?

Eric M. Ruderman, MD


December 23, 2021

Gout and pseudogout, osteoarthritis (OA), reactive arthritis (formerly called "Reiter syndrome"), rheumatoid arthritis (RA), and septic arthritis are important differential diagnoses to consider when evaluating patients with signs and symptoms suspicious for PsA. Other diseases to consider in the workup include enteropathic arthritis, systemic lupus erythematosus, secondary syphilis, and ankylosing spondylitis.

Tinea versicolor, Lyme disease, and HFMD are associated with specific rashes but lack the skin changes associated with PsA.

Like PsA, iron deficiency anemia, vitamin D deficiency, and vitamin B12 deficiency can cause fatigue; however, these conditions lack the other presenting features of PsA such as joint pain, swelling, rash, and skin and nail changes. Likewise, hypothyroidism, multiple sclerosis, and Epstein-Barr virus infection are not part of the differential workup of PsA because they also lack the presenting features of PsA.

Learn more about the differential diagnoses of PsA.


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